Best SAM-e 400 contains 400 mg of active SAM-e in each tablet.  Doctor’s Best utilizes only the highest quality Italian SAM-e available on the market.  This ensures the most potent SAM-e product with the highest percentage of the active S,S form per serving.

S-Adenosyl Methionine (SAM-e) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system.  Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems.  Methylation occurs billions of times daily in the many organs of the body.  SAM-e is involved in numerous biochemical reactions in tissues including the liver, joints and brain.  SAM-e is also required for the biosynthesis of critical neurotransmitters and hormones.  SAM-e is the methyl donor that catalyzes the production of epinephrine, melatonin, glutathione and the amino acids cysteine and taurine.   SAM-e is also known to upregulate the production of critical membrane phospholipids including phosphatidylcholine.   SAM-e is also a sulfur donor and, for this reason, is critical for the formation of sulfur-containing proteoglycans in joint connective tissue.

Ingredients: S-Adenosyl Methionine (from 800 mg of SAM-etosylate disulfate) 400 mg

Other Ingredients: Cellulose, mannitol, hydroxypropyl methylcellulose phthalate, citric acid, sodium starch glycolate, triacetin, modified cellulose gum, stearic acid, silica, titanium dioxide, yellow ochre

Warning: Individuals diagnosed with manic depression should avoid SAM-e supplementation, as it may aggravate the manic phase.